on the effects of post-vaccination 3 We’ll answer all your questions!

(The following is based on what I have heard from doctors and includes my own analogies, so please consider it at a casual reading level.)

Q1. Do vaccines work on mutants that get stronger and stronger one after another?

The mRNA vaccine is considered effective because it is the type that can continue to respond to successively derived mutant strains.

First, the basics. There are two types of vaccines (“mRNA” and “adenovirus”).
Pfizer/Moderna is “mRNA”.
AstraZeneca/Johnson and Johnson is “Adenovirus”
mRNA” is effective against existing mutant strains. (Not in an epidemiological study, but experimentally)

In Europe, many people have taken AstraZeneca, but Pfizer is more resistant to mutant strains, and trials have just started to see if new mutant strains (Delta, Epsilon, Kappa) will work in people who have had two mRNA shots and have antibodies, but mRNA is not a good choice for cellular immunity even if antibody titers drop. Memory is retained, so you should be fine. Even if a person contracted a mutant strain of corona after two inoculations, severe illness could be prevented.

Since coronas, like the flu, will be with us forever, society will treat them as if they were the flu by continuing to deal with mutant strains.

◆ ◆ Reference

An mRNA vaccine (messenger RNA) is a
A vaccine that allows the police to determine the face of the culprit (virus) from the blueprints and catch it immediately.
https://kujira-zaitaku.clinic/blog/957.html

Even with the mutant strain, more than 90% of those vaccinated twice were able to produce neutralizing antibodies. Yokohama City University confirmed vaccine efficacy.
https://scienceportal.jst.go.jp/newsflash/20210513_n01/

After vaccination with new corona vaccine (mRNA vaccine), lymph node germinal centers remain active even 15 weeks after vaccination, and many people who have received two doses of mRNA vaccine may not need additional vaccinations
https://www.nature.com/articles/s41586-021-03738-2

Pfizer, U.S., to develop delta strain vaccine; clinical trials to begin in August.
https://www.jiji.com/jc/article?k=2021070900469&g=int

The “cocktail method,” in which an “adenovirus vaccine” is given followed by an “mRNA vaccine,” is also recommended. / “Alternate vaccination with different coronaviruses strongly recommended, Germany.”
https://www.cnn.co.jp/world/35173343.html

Q2. When can antibodies be produced after vaccination?

Generally, the second From the second inoculation 2 Weeks to 4 Can be done after a week.

If you want to know your antibodies, you can do the “IgG antibody test” (anti S-protein antibody = a blood test to see if antibodies have been produced). The blood test measures the antibody titer in the blood and determines whether it is negative or positive. *S = spike

In the United States, patients with low antibody titers 3 Vaccinated three times. (In the U.S., you can get the vaccine without coupons.)

Stronger adverse reactions and fever, e.g., Pfizer and Moderna “… mRNA Vaccine” ( PEG ＝(= reacts with the polyethylene glycol component) is a factor. PEG is found in cosmetics, tablet coatings, ultrasound jelly, ointments, and many other medications handled in the medical field. Repeated contact with PEG Antibodies to the vaccine have been formed, and the vaccine has been used to PEG is introduced into the body in large quantities, the body reacts violently. That is why 2 The second one is more painful.

There is some debate as to whether or not there is a relationship between this adverse reaction and efficacy, but honestly, it is impossible to tell without a “Iig antibody test” to determine the amount of antibody numerically. Therefore, after 4 weeks after the second vaccination, a blood test (11,000 yen, including the cost of the test) is required at a specialized clinic, although there is a fee for this test. The cost of the blood test (11,000 yen; certificate issued at an additional 3,000 yen) should be paid at a specialized clinic four weeks after the two vaccinations. If the antibody level is insufficient, that is, if it remains negative, the third inoculation should be given. Incidentally, even if a saliva test is done with a cheap PCR test kit in the early days after antibody acquisition, it may remain negative. Saliva is really not reliable, so be careful.

◆ Reference
Duration of the novel coronavirus antibody test
https://www.aozoracl.com/corona_kikan

Clinic where “IgG antibody test” is available after vaccination with new coronavirus vaccine. Mame Clinic” (in front of Kudanshita Station, Ikebukuro East Exit, Shinbashi Station, Shinjuku South Exit, and Shibuya Station)
https://mame-clinic.jp/covid19-igg

Pfizer “3 times immunization” Antibody level increased 5 to 10 times
https://news.tv-asahi.co.jp/news_international/articles/000222007.html

Q3. How long do vaccine effects last?

Antibody titers are halved in six months, but where 50 is sufficient, for example, it feels like there are 1,000.
Then, even if 1,000 is halved in six months, there is still a resistance of 500. In another six months, 250; in another six months, 125; and in another six months, 62, which would be good enough for two and a half years.
Chief Cabinet Secretary Kato went on about not lasting a year, but he may not be particularly well-founded.

It is now known that even if the antibodies are apparently lowered, they are actually stored in memory, and if there is some stimulus, more and more antibodies are produced within a week.
Therefore, it is conceivable that those who have been vaccinated may be fine for a longer period of time than expected.

Maybe a method of measuring the part that is in memory will be developed in the future.

… So, let’s vaccinate everyone!

◆ ◆ Reference

Vaccines made by Pfizer and Moderna: Effects last for several years?
https://www.nikkei.com/article/DGXZQOGN29EBB0Z20C21A6000000/

Even 15 weeks after vaccination with the new corona vaccine (mRNA vaccine), lymph node germinal centers remain active, and many who have received two doses of mRNA vaccine may not need additional doses. (“Nature” article 2021, Jun. 28) by @EARL_COVID19_tw
https://www.nature.com/articles/s41586-021-03738-2

The fastest practical application of a vaccine in history, the creator talks about the future of mRNA technology.
https://www.technologyreview.jp/s/239784/the-next-act-for-messenger-rna-could-be-bigger-than-covid-vaccines/?fbclid=IwAR3Yy89PvxQ6X9Jh6HHUYCqipc3cVnD65b7aHgQ7Qn-_lhU51rWVrEFh4Xs

PS:
I got my vaccine certificate on a t-shirt! Now I can say what’s inside without forgetting at the airport!